Ttreat high blood pressure and anxiety, PTSD, and panic disorder.
alpha-adrenergic blocker
It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors
Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity
The antihypertensive characteristics of prazosin make it a second-line choice for the treatment of high blood pressure
Prazosin is also useful in treating urinary hesitancy associated with prostatic hyperplasia, blocking alpha-1 receptors, which control constriction of both the prostate and ureters
This medication has shown to be effective in treating severe nightmares in children and people with PTSD symptoms.
side effect
Side effects of prazosin include orthostatic hypotension, syncope, and nasal congestion. The orthostatic hypotension and syncope are associated with the body's poor ability to control blood pressure without active alpha-adrenergic receptors. Patients on prazosin should be told not to stand up too quickly, since their poor baroreflex may cause them to faint as all their blood rushes to their feet. The nasal congestion is due to dilation of vessels in the nasal mucosa.
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One very rare side effect of prazosin is priapism.[5]!!!!!
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Prazosin in scorpion stings
Since 1983 prazosin has revolutionized the management of severe scorpion stings
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uses/indications
Prazosin is less well studied in dogs than hydralazine, and its capsule
dosage form makes it less convenient for dosing. Prazosin, however,
appears to have fewer problems with causing tachycardia, and its
venous dilation effects may be an advantage over hydralazine when
preload reduction is desired. It could be considered for therapy for
the adjunctive treatment of CHF, particularly when secondary to
mitral or aortic valve insufficiency when hydralazine is ineffective
or not tolerated. Prazosin may also be used for the treatment of
systemic hypertension or pulmonary hypertension in dogs.
Pharmacology/actions
Prazosin’s effects are a result of its selective, competitive inhibition
of alpha1-adrenergic receptors. It reduces blood pressure and pe-ripheral vascular resistance and, unlike hydralazine, has dilatory ef-fects on both the arterial and venous side.
Prazosin significantly reduces systemic arterial and venous blood
pressures, and right atrial pressure; cardiac output is increased in
patients with CHF. Moderate reductions in blood pressure, pulmo-nary vascular resistance, and systemic vascular resistance are seen
in these patients. Heart rates can be moderately decreased or un-changed. Unlike hydralazine, prazosin does not seem to increase
renin release so diuretic therapy is not mandatory with this agent
(but is usually beneficial in CHF)
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