Prazosin. Minipress

Ttreat high blood pressure and anxiety, PTSD, and panic disorder.

alpha-adrenergic blocker

It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors

Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity

 The antihypertensive characteristics of prazosin make it a second-line choice for the treatment of high blood pressure

Prazosin is also useful in treating urinary hesitancy associated with prostatic hyperplasia, blocking alpha-1 receptors, which control constriction of both the prostate and ureters

This medication has shown to be effective in treating severe nightmares in children and people with PTSD symptoms.

side effect

Side effects of prazosin include orthostatic hypotension, syncope, and nasal congestion. The orthostatic hypotension and syncope are associated with the body's poor ability to control blood pressure without active alpha-adrenergic receptors. Patients on prazosin should be told not to stand up too quickly, since their poor baroreflex may cause them to faint as all their blood rushes to their feet. The nasal congestion is due to dilation of vessels in the nasal mucosa.

응??

One very rare side effect of prazosin is priapism.^[5]!!!!!

YE~~~~~~ ㅋㅋㅋㅋㅋ

Prazosin in scorpion stings

Since 1983 prazosin has revolutionized the management of severe scorpion stings

plunm...

uses/indications 

Prazosin is less well studied in dogs than hydralazine, and its capsule 

dosage form makes it less convenient for dosing. Prazosin, however, 

appears to have fewer problems with causing tachycardia, and its 

venous dilation effects may be an advantage over hydralazine when 

preload reduction is desired. It could be considered for therapy for 

the adjunctive treatment of CHF, particularly when secondary to 

mitral or aortic valve insufficiency when hydralazine is ineffective 

or not tolerated. Prazosin may also be used for the treatment of 

systemic hypertension or pulmonary hypertension in dogs.

Pharmacology/actions 

Prazosin’s effects are a result of its selective, competitive inhibition 

of alpha1-adrenergic receptors. It reduces blood pressure and pe-ripheral vascular resistance and, unlike hydralazine, has dilatory ef-fects on both the arterial and venous side.

Prazosin significantly reduces systemic arterial and venous blood 

pressures, and right atrial pressure; cardiac output is increased in 

patients with CHF. Moderate reductions in blood pressure, pulmo-nary vascular resistance, and systemic vascular resistance are seen 

in these patients. Heart rates can be moderately decreased or un-changed. Unlike hydralazine, prazosin does not seem to increase 

renin release so diuretic therapy is not mandatory with this agent 

(but is usually beneficial in CHF)

이런 약이구나...